Home Product Guides Nattokinase: Complete Product Guide

Nattokinase: Complete Product Guide

Last updated on Feb 12, 2026

Nattokinase: Complete Product Guide

What is Nattokinase?

Nattokinase is a powerful enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. It has been used in Japan for over 1,000 years and is now recognized worldwide for its cardiovascular benefits.

Key Benefits

Cardiovascular Support

  • Supports healthy blood circulation

  • Promotes cardiovascular health

  • Supports healthy blood pressure already within normal range

  • May help maintain healthy blood viscosity

Circulatory Health

  • Supports healthy blood flow throughout the body

  • May help maintain vascular health

  • Supports overall circulatory system function

Fibrinolytic Activity

  • Contains natural fibrinolytic enzymes

  • May help support the body's natural clot-dissolving processes

  • Supports healthy fibrin metabolism

How to Take Nattokinase

Recommended Dosage:

  • Check your bottle label for specific dosage (typically measured in FUs - Fibrinolytic Units)

  • Common dosages range from 2,000 to 4,000 FU per day

  • Usually taken once or twice daily

Best Time to Take:

  • On an empty stomach is ideal - Take at least 1 hour before meals or 2 hours after meals

  • This allows for better absorption and activity

  • Many people take it first thing in the morning or before bed

  • Can be taken with water

With or Without Food:
Unlike many supplements, Nattokinase is most effective when taken on an empty stomach, as food can interfere with enzyme activity.

When to Expect Results

  • Initial circulation effects: Some people notice improved circulation within 2-4 weeks

  • Full cardiovascular benefits: Take consistently for at least 2 months

  • Blood pressure effects: If monitoring blood pressure, you may see gradual improvements over 4-8 weeks

  • Overall wellness: Cardiovascular benefits develop over time with consistent use

Who Should Consider Nattokinase?

Nattokinase may be beneficial for people looking to:

  • Support cardiovascular health

  • Maintain healthy circulation

  • Support healthy blood pressure already within normal range

  • Promote vascular wellness

  • Support overall heart health as they age

Drug Interactions - VERY IMPORTANT!

DO NOT take Nattokinase if you:

  • Take blood thinners (warfarin, Coumadin, heparin, Plavix, aspirin therapy)

  • Take anti-platelet medications

  • Have a bleeding disorder

  • Are scheduled for surgery within 2 weeks

  • Are pregnant or nursing

Consult your doctor before taking if you:

  • Take any medications that affect blood clotting

  • Have a history of stroke or bleeding disorders

  • Take blood pressure medications

  • Have any cardiovascular conditions

Nattokinase has blood-thinning properties, which is why it's crucial to discuss it with your healthcare provider if you're on any medications or have any medical conditions.

Potential Side Effects

Most people tolerate Nattokinase well, but some may experience:

  • Mild digestive discomfort

  • Increased bleeding tendency (if taking too much or with blood thinners)

  • Allergic reactions (rare, but possible if allergic to soy)

Stop taking and contact your doctor if you experience:

  • Unusual bleeding or bruising

  • Blood in urine or stool

  • Prolonged bleeding from cuts

  • Any signs of allergic reaction

Surgery Precautions

Stop taking Nattokinase at least 2 weeks before any scheduled surgery due to its blood-thinning effects. Inform your surgeon that you've been taking Nattokinase.

Tips for Best Results

  1. Take on an empty stomach - This is crucial for optimal absorption

  2. Be consistent - Take at the same time each day

  3. Morning or bedtime - Many people find these times easiest for empty-stomach dosing

  4. Stay hydrated - Drink plenty of water throughout the day

  5. Give it time - Cardiovascular benefits develop over weeks and months

  6. Monitor your health - Work with your doctor to track blood pressure or other metrics

Storage

  • Store in a cool, dry place away from direct sunlight

  • Keep bottle tightly closed

  • Some formulations may benefit from refrigeration (check your label)

  • Do not store in humid environments like bathrooms

  • Check expiration date on bottle

Quality & Testing

All Luma Nutrition Nattokinase is:

  • Third-party tested for purity and potency

  • Manufactured in the USA in GMP and FDA certified facilities

  • NSF certified

  • Standardized for fibrinolytic activity (FU)

  • Free from contaminants and heavy metals

You can request a Certificate of Analysis (COA) by emailing help@lumanutrition.com with your bottle's lot number.

Frequently Asked Questions

Is Nattokinase derived from soy? Can I take it if I have a soy allergy?
Yes, Nattokinase is derived from fermented soybeans. However, the fermentation process typically removes most soy proteins. If you have a soy allergy, consult your doctor before taking it.

Can I take Nattokinase with aspirin?
No, you should not combine Nattokinase with aspirin or any blood-thinning medications without explicit approval from your healthcare provider due to increased bleeding risk.

Will Nattokinase thin my blood too much?
When taken at recommended doses and without other blood thinners, Nattokinase is generally safe. However, you should have your doctor monitor you if you have any concerns about bleeding or clotting.

Can I take Nattokinase with other supplements?
Generally yes, but avoid combining with supplements that have blood-thinning effects (like high-dose fish oil, ginkgo biloba, garlic extract) without medical supervision. Always inform your doctor of all supplements you're taking.

What's the difference between FU and mg?
FU (Fibrinolytic Units) measures the enzyme activity of Nattokinase, while mg measures the weight. FU is more important because it indicates the actual potency and effectiveness of the enzyme.

How long can I take Nattokinase?
Many people take Nattokinase long-term for ongoing cardiovascular support. Discuss your specific situation and duration with your healthcare provider.

Need More Information?

  • Check the detailed label on your bottle

  • Visit the Nattokinase product page on lumanutrition.com

  • Contact our support team at help@lumanutrition.com

  • Request a Certificate of Analysis for detailed testing results

  • Consult your healthcare provider before starting - especially important for this supplement

Our Guarantee

Try Nattokinase risk-free with our 90-day money-back guarantee. If it doesn't work for you, return it for a full refund - even if the bottle is empty.

Safety First

Nattokinase is a powerful enzyme with significant cardiovascular effects. While it's safe for many people, it's essential to discuss it with your healthcare provider, especially if you take any medications or have any medical conditions. Your doctor can help determine if Nattokinase is appropriate for your specific health situation.